Water → HCID 86689312, compound

HRID 1852496Notes

Reaction equation

HRID 1852496 reaction equation
[N+:1]([C:4]1[C:12]([NH:13][C:14]2[CH:15]=[C:16]([CH:19]=[CH:20][CH:21]=2)[C:17]#[N:18])=[CH:11][CH:10]=[C:9]2[C:5]=1[CH2:6][CH2:7][CH2:8]2)([O-])=O.O>O1CCCC1.CO.[C].[Pd]>[NH2:1][C:4]1[C:12]([NH:13][C:14]2[CH:15]=[C:16]([CH:19]=[CH:20][CH:21]=2)[C:17]#[N:18])=[CH:11][CH:10]=[C:9]2[C:5]=1[CH2:6][CH2:7][CH2:8]2

Participants

6

Reactant 2

HCID 962WaterHCID 86689311HCID 86689311, compound

Product 1

HCID 86689312HCID 86689312, compoundYield 100.3%

Reagents, catalysts & solvents 3

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

3-(4-Nitroindan-5-ylamino)benzonitrile (0.84 g, 3.00 mmol) was dissolved in tetrahydrofuran (84 mL)-methanol (21 mL). To the solution was added water-containing 5% palladium-carbon (0.08 g). The mixture was stirred under hydrogen atmosphere at room temperature for 16 hours. Insoluble was removed by filtration. The filtrate was concentrated under reduced pressure to give the titled compound as yellowish brown crystal (0.75 g, yield 100%).

Workup

  1. customInsoluble was removed by filtration
  2. concentrationThe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-6c3ead14e6c24106bf099295fa346ca4
Source dataset
uspto-grants-2015_02
Patent number
US08962613B2

Reaction notes

Loading…