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HRID1852702

反应详情

EQUATION

反应方程式

HRID 1852702 的结构方程式

REACTANTS

反应物

1
结构：CC(C)(C)OC(=O)Nc1cc(Cl)nc(Cl)c1NC[C@H]1CC[C@H](C)CC1
HCID178452762

未命名化合物

PRODUCTS

生成物

1
结构：C[C@H]1CC[C@H](CNc2c(N)cc(Cl)nc2Cl)CC1
HCID178461256

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：C1COCCO1.Cl
溶剂HCID20443148

1,4-Dioxane hydrochloride

C4H9ClO2

PROCEDURE

实验过程

A solution of tert-butyl (2,6-dichloro-3-(((trans-4-methylcyclohexyl)methyl)amino)pyridin-4-yl)carbamate (150 g, 0.386 mol) in HCl/1,4-dioxane (4 M, 3.0 L) was stirred at 45° C. for 15 h. The mixture was concentrated under reduced pressure to give crude 2,6-dichloro-N3-((trans-4-methylcyclohexyl)methyl)pyridine-3,4-diamine.

WORKUP

后处理

  1. concentrationThe mixture was concentrated under reduced pressure