3-(Tributylstannanyl)pyridazine → Hydrochloric Acid

HRID 1852872Notes

Reaction equation

HRID 1852872 reaction equation
[Cl:1][C:2]1[C:7]2[N:8]([CH2:11][C@H:12]3[CH2:17][CH2:16][C@H:15]([CH3:18])[CH2:14][CH2:13]3)[CH:9]=[N:10][C:6]=2[CH:5]=[C:4]([Cl:19])[N:3]=1.[O:20]1[CH2:25][CH2:24][NH:23][C@@H:22]2[CH2:26][CH2:27][CH2:28][C@@H:21]12.C([Sn](CCCC)(CCCC)C1N=NC=CC=1)CCC>>[ClH:1].[Cl:1][C:2]1[C:7]2[N:8]([CH2:11][C@H:12]3[CH2:17][CH2:16][C@H:15]([CH3:18])[CH2:14][CH2:13]3)[C:9]([N:23]3[CH2:24][CH2:25][O:20][C@@H:21]4[CH2:28][CH2:27][CH2:26][C@@H:22]34)=[N:10][C:6]=2[CH:5]=[C:4]([Cl:19])[N:3]=1

Participants

5

Reactant 3

HCID 27632603-(Tributylstannanyl)pyridazineHCID 28796216(4aR,7aR)-octahydrocyclopenta[b][1,4]oxazineHCID 178461251HCID 178461251, compound

Product 2

HCID 313Hydrochloric AcidHCID 178461234HCID 178461234, compound

Procedure

Using a procedure analagous to that described in Example 2.1 (Steps 1 and 2) and starting with 4,6-dichloro-3-((trans-4-methylcyclohexyl)methyl)-3H-imidazo[4,5-c]pyridine (Preparative Example 2.3) and (trans)-octahydrocyclopenta[b][1,4]oxazine.HCl (purchased from Enamine), 4,6-dichloro-2-[(trans)-hexahydrocyclopenta[b][1,4]oxazin-4(4aH)-yl]-3-[(trans-4-methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridine (racemic) was prepared. Preparative Example 18.2 3-(tributylstannanyl)pyridazine

Sources & evidence

ORD record
ord-38e189ccef644517a38e62948f0cc1ad
Source dataset
uspto-grants-2015_02
Patent number
US08962611B2

Reaction notes

Loading…