反应详情

温度

60 °C

To a solution of 2-(3-chloro-pyrazin-2-yl)-malonic acid diethyl ester (10.0 g) in ethanol (100 ml) was added 2M sodium hydroxide (100 ml) and the reaction mixture heated to 60° C. for 4 hours. The reaction mixture was cooled to ambient temperature then poured onto water and 1M hydrochloric acid followed by extraction with ethyl acetate (3×). The combined organic layers were dried (magnesium sulfate), filtered and the filtrate concentrated to give the crude title compound as a yellow solid. The solid was slurried with diethylether to give (3-chloro-pyrazin-2-yl)-acetic acid (4.35 g). MH+=173, RT=0.72 min (Method A).

1. temperatureThe reaction mixture was cooled to ambient temperature
2. extractionfollowed by extraction with ethyl acetate (3×)
3. dry with materialThe combined organic layers were dried (magnesium sulfate)
4. filtrationfiltered
5. concentrationthe filtrate concentrated
6. customto give the crude title compound as a yellow solid