反应详情

Lithium hydroxide hydrate (0.0813 g, 1.94 mmol) was dissolved in water (2 mL) and was added to a solution of dimethyl 3-(4-(7-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-c]pyrimidin-5-yl)-1H-pyrazol-1-yl)pentanedioate (0.205 g, 0.484 mmol) in MeOH (4 mL). After stirring 3 days the reaction was concentrated to remove the MeOH and was then acidified to pH 4 with 1 N HCl (approximately 2 mL). Cooling resulted in a solid which was filtered and washed with MeOH. The filtrate was slightly concentrated to provide a second crop of product which was combined to provide 3-(4-(7-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-c]pyrimidin-5-yl)-1H-pyrazol-1-yl)pentanedioic acid (125 mg, 65% yield). MS (apci) m/z=396.2 (M+H).

1. concentrationwas concentrated
2. customto remove the MeOH
3. temperatureCooling
4. customresulted in a solid which
5. filtrationwas filtered
6. washwashed with MeOH
7. concentrationThe filtrate was slightly concentrated
8. customto provide a second crop of product which