Trifluoroacetic acid → 5-(5-(1H-pyrazol-4-yl)imidazo[1,2-c]pyrimidin-7-yl)-2-methylthiazole

Participants

Reaction Steps

2-methyl-5-(5-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazol-4-yl)imidazo[1,2-c]pyrimidin-7-yl)thiazole (0.196 g, 0.475 mmol) was dissolved in 3 mL of DCM before TFA (2.0 mL, 26.0 mmol) was added slowly at room temperature. The reaction was allowed to stir at room temperature for 8 hours. The reaction mixture was concentrated under reduced pressure to afford the crude material. The crude material was purified via column chromatography, eluting with 5% MeOH in DCM with 1% NH4OH to afford the title compound (0.087 g, 64.9% yield). MS (apci) m/z=283.1 (M+H).

Provenance & Evidence