反应详情

In a 100 mL flask, methyl 5-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazol-4-yl)imidazo[1,2-c]pyrimidine-7-carboxylate (0.477 g, 1.28 mmol) (Example 45; Step C) was dissolved in DCM (12.8 mL, 1.28 mmol). To this was added 4N HCl in dioxane (4.79 mL, 19.2 mmol). After stirring at ambient temperature for 4 hours, the reaction mixture was concentrated down to remove solvents. The resultant solid was diluted in DCM, sonicated and filtered to afford 0.363 g (100% yield) of the HCl salt as a light yellow solid. MS (apci) m/z=244.3 (M+H).

1. concentrationthe reaction mixture was concentrated down
2. customto remove solvents
3. additionThe resultant solid was diluted in DCM
4. customsonicated
5. filtrationfiltered