HCID 67450359, compound → HCID 86685337, compound

HRID 1853077Notes

Reaction equation

HRID 1853077 reaction equation
[CH3:1][N:2]1[CH:6]=[C:5]([C:7]2[N:12]=[C:11]([C:13]3[CH:14]=[N:15][NH:16][CH:17]=3)[N:10]3[CH:18]=[CH:19][N:20]=[C:9]3[CH:8]=2)[CH:4]=[N:3]1.[CH2:21]1[C:24]2([CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]2)[CH2:23][C:22]1=[CH:30][C:31]#[N:32]>>[CH3:1][N:2]1[CH:6]=[C:5]([C:7]2[N:12]=[C:11]([C:13]3[CH:14]=[N:15][N:16]([C:22]4([CH2:30][C:31]#[N:32])[CH2:23][C:24]5([CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]5)[CH2:21]4)[CH:17]=3)[N:10]3[CH:18]=[CH:19][N:20]=[C:9]3[CH:8]=2)[CH:4]=[N:3]1

Participants

3

Reactant 2

HCID 67450359HCID 67450359, compoundHCID 674525377-(1-methyl-1H-pyrazol-4-yl)-5-(1H-pyrazol-4-yl)imidazo[1,2-c]pyrimidine

Product 1

HCID 86685337HCID 86685337, compoundYield 37.3%

Procedure

This was prepared from 7-(1-methyl-1H-pyrazol-4-yl)-5-(1H-pyrazol-4-yl)imidazo[1,2-c]pyrimidine (100 mg; 0.377 mmol) and 2-(spiro[3.5]nonan-2-ylidene)acetonitrile (91 mg; 0.565 mmol) using the procedure described in Example 148, Step D to give the desired product (60 mg). MS (apci) m/z=427.2 (M+H).

Sources & evidence

ORD record
ord-a8a88f8e73dc49bebe43b706eaf381ec
Source dataset
uspto-grants-2015_02
Patent number
US08962596B2

Reaction notes

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