Hydrochloric Acid → HCID 67458295, compound

Participants

Reaction Steps

tert-Butyl 3-(cyanomethyl)-3-(4-(7-(4-methoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl)-1H-pyrazol-1-yl)azetidine-1-carboxylate (1.60 g, 3.30 mmol) was suspended in 20 mL of 1,4-dioxane and then HCl (41.2 mL, 165 mmol) (4 M in dioxane) was added in one portion. The reaction was stirred at ambient temperature overnight, then concentrated under reduced pressure to afford the crude material, which was used in the next step without further purification.

Provenance & Evidence