Hydrochloric Acid → HCID 67458295, compound

HRID 1853085Notes

Reaction equation

HRID 1853085 reaction equation
[C:1]([CH2:3][C:4]1([N:15]2[CH:19]=[C:18]([C:20]3[N:25]4[CH:26]=[CH:27][N:28]=[C:24]4[CH:23]=[C:22]([C:29]4[CH:34]=[CH:33][C:32]([O:35][CH3:36])=[CH:31][CH:30]=4)[N:21]=3)[CH:17]=[N:16]2)[CH2:7][N:6](C(OC(C)(C)C)=O)[CH2:5]1)#[N:2].[ClH:37]>O1CCOCC1>[ClH:37].[ClH:37].[CH3:36][O:35][C:32]1[CH:31]=[CH:30][C:29]([C:22]2[N:21]=[C:20]([C:18]3[CH:17]=[N:16][N:15]([C:4]4([CH2:3][C:1]#[N:2])[CH2:7][NH:6][CH2:5]4)[CH:19]=3)[N:25]3[CH:26]=[CH:27][N:28]=[C:24]3[CH:23]=2)=[CH:34][CH:33]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86685342HCID 86685342, compound

Product 1

HCID 67458295HCID 67458295, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

tert-Butyl 3-(cyanomethyl)-3-(4-(7-(4-methoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl)-1H-pyrazol-1-yl)azetidine-1-carboxylate (1.60 g, 3.30 mmol) was suspended in 20 mL of 1,4-dioxane and then HCl (41.2 mL, 165 mmol) (4 M in dioxane) was added in one portion. The reaction was stirred at ambient temperature overnight, then concentrated under reduced pressure to afford the crude material, which was used in the next step without further purification.

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-defa09aed6674c05bad85f4b64edd999
Source dataset
uspto-grants-2015_02
Patent number
US08962596B2

Reaction notes

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