Hydrochloric Acid → HCID 67452576, compound

HRID 1853122Notes

Reaction equation

HRID 1853122 reaction equation
C[O:2][C:3]1[N:8]=[C:7]([C:9]([CH3:13])([CH3:12])[C:10]#[N:11])[CH:6]=[CH:5][CH:4]=1.Cl>O1CCOCC1>[CH3:13][C:9]([C:7]1[NH:8][C:3](=[O:2])[CH:4]=[CH:5][CH:6]=1)([CH3:12])[C:10]#[N:11]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67453713HCID 67453713, compound

Product 1

HCID 67452576HCID 67452576, compoundYield 380.7%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
190 °C

Procedure

To a 20 dram microwave vial was added 2-(6-methoxypyridin-2-yl)-2-methylpropanenitrile (7 g, 40 mmol) and 4N HCl in dioxane (15 mL). The reaction was then sealed and heated in a microwave reactor at 190° C. for 30 min. This reaction was repeated six times using the procedure above. These reactions were combined and filtered. The resultant white solid was washed with 20% EtOAc/hexanes and then dried in vacuo to afford 2-methyl-2-(6-oxo-1,6-dihydropyridin-2-yl)propanenitrile (24.7 g, 77%) as a white solid.

Workup

  1. customThe reaction was then sealed
  2. filtrationfiltered
  3. washThe resultant white solid was washed with 20% EtOAc/hexanes
  4. customdried in vacuo

Sources & evidence

ORD record
ord-3125debbbe4f406389c7ffee01232353
Source dataset
uspto-grants-2015_02
Patent number
US08962632B2

Reaction notes

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