Water → HCID 178508285, compound

HRID 1853132Notes

Reaction equation

HRID 1853132 reaction equation
O.Cl.[C:3]([NH2:11])(=[NH:10])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.C([O-])(=O)C.[Na+].N[C:18]1[NH:22][N:21]=[C:20]([NH:23][C:24]2[CH:29]=[CH:28][C:27]([Br:30])=[CH:26][CH:25]=2)[C:19]=1[C:31]#[N:32].O>C(O)(=O)C>[NH2:32][C:31]1[N:11]=[C:3]([C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=2)[N:10]=[C:18]2[NH:22][N:21]=[C:20]([NH:23][C:24]3[CH:29]=[CH:28][C:27]([Br:30])=[CH:26][CH:25]=3)[C:19]=12

Participants

6

Reactant 4

HCID 962WaterHCID 517045Sodium AcetateHCID 15195394HCID 15195394, compoundHCID 16219042Benzamidine HCl hydrate

Product 1

HCID 178508285HCID 178508285, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

1.87 g (10.7 mmol) benzamidin hydrochloride hydrate and 0.89 g (10.7 mmol) sodium acetate are added to 1.0 g (3.6 mmol) 5-amino-4-cyano-3-(4-bromophenyl)aminopyrazol in 20 ml ethanoic acid by stirring. The reaction mixture is boiled for a period of 4 h, treated with 50 ml water, filtered and washed with 20 ml of cold methanol and 20 ml of cold ester. The raw product is purified by means of crystallization from ethanol.

Workup

  1. filtrationfiltered
  2. washwashed with 20 ml of cold methanol and 20 ml of cold ester
  3. customThe raw product is purified by means of crystallization from ethanol

Sources & evidence

ORD record
ord-6a38cddeda5d4ada98e708d23fef4d58
Source dataset
uspto-grants-2015_02
Patent number
US08962634B2

Reaction notes

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