O-tert-butylhydroxylamine hydrochloride → HCID 86673027, compound

HRID 1853254Notes

Reaction equation

HRID 1853254 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[O:8][C:7]([C:12]1[N:13]=[CH:14][C:15]3[C:20]([CH:21]=1)=[CH:19][CH:18]=[CH:17][CH:16]=3)=[CH:6][C:5]2=O.Cl.[C:24]([O:28][NH2:29])([CH3:27])([CH3:26])[CH3:25]>CO>[C:24]([O:28][N:29]=[C:5]1[C:4]2[C:9](=[CH:10][CH:11]=[C:2]([Br:1])[CH:3]=2)[O:8][C:7]([C:12]2[N:13]=[CH:14][C:15]3[C:20]([CH:21]=2)=[CH:19][CH:18]=[CH:17][CH:16]=3)=[CH:6]1)([CH3:27])([CH3:26])[CH3:25]

Participants

4

Reactant 2

HCID 2777906O-tert-butylhydroxylamine hydrochlorideHCID 67194118HCID 67194118, compound

Product 1

HCID 86673027HCID 86673027, compoundYield 76%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

6-bromo-2-isoquinolin-3-yl-chromen-4-one O-tert-butyl oxime was prepared using the method D (step 1) illustrated in example 1B. 6-bromo-2-isoquinolin-3-yl-chromen-4-one (600 mg, 1.7 mmol) was treated with O-tert-butyl-hydroxylamine hydrochloride (427 mg, 3.4 mmol) in methanol (10 ml) under microwave irradiation to yield 6-bromo-2-isoquinolin-3-yl-chromen-4-one O-tert-butyl oxime (546 mg, 76%) as a yellow solid.

Workup

  1. custom6-bromo-2-isoquinolin-3-yl-chromen-4-one O-tert-butyl oxime was prepared

Sources & evidence

ORD record
ord-99b5dea9f4ee48d1a00849f63e981e7f
Source dataset
uspto-grants-2015_02
Patent number
US08962627B2

Reaction notes

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