Bis(2-Methoxyethyl)amine → HCID 131732479, compound

HRID 1853322Notes

Reaction equation

HRID 1853322 reaction equation
C([O:5][N:6]=[C:7]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([O:17][CH2:18][CH2:19][Cl:20])[CH:15]=2)[O:10][C:9]([C:21]2[N:26]=[CH:25][N:24]3[CH:27]=[CH:28][CH:29]=[C:23]3[CH:22]=2)=[CH:8]1)(C)(C)C.[CH3:30][O:31][CH2:32][CH2:33][NH:34][CH2:35][CH2:36][O:37][CH3:38]>>[ClH:20].[CH3:30][O:31][CH2:32][CH2:33][N:34]([CH2:35][CH2:36][O:37][CH3:38])[CH2:19][CH2:18][O:17][C:14]1[CH:15]=[C:16]2[C:11](=[CH:12][CH:13]=1)[O:10][C:9]([C:21]1[N:26]=[CH:25][N:24]3[CH:27]=[CH:28][CH:29]=[C:23]3[CH:22]=1)=[CH:8][C:7]2=[N:6][OH:5]

Participants

3

Reactant 2

HCID 2383Bis(2-Methoxyethyl)amineHCID 866730766-(2-chloro-ethoxy)-2-pyrrolo[1,2-c]pyrimidin-3-yl-chromen-4-one O-tert-butyl oxime

Product 1

HCID 131732479HCID 131732479, compound

Procedure

6-(2-[bis-(2-methoxy-ethyl)-amino]-ethoxy)-2-pyrrolo[1,2-c]pyrimidin-3-yl-chromen-4-one oxime, hydrochloride was prepared in 40% overall yield using the method described in example 87, starting from 6-(2-chloro-ethoxy)-2-pyrrolo[1,2-c]pyrimidin-3-yl-chromen-4-one O-tert-butyl oxime (example 87B) and bis-(2-methoxy-ethyl)-amine.

Workup

  1. customoverall yield

Sources & evidence

ORD record
ord-0e37e072809d4a149681160614a11a2d
Source dataset
uspto-grants-2015_02
Patent number
US08962627B2

Reaction notes

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