4-(Trifluoromethyl)piperidine → HCID 131732484, compound

HRID 1853327Notes

Reaction equation

HRID 1853327 reaction equation
C([O:5][N:6]=[C:7]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([O:17][CH2:18][CH2:19][Cl:20])[CH:15]=2)[O:10][C:9]([C:21]2[N:26]=[CH:25][N:24]3[CH:27]=[CH:28][CH:29]=[C:23]3[CH:22]=2)=[CH:8]1)(C)(C)C.[F:30][C:31]([F:39])([F:38])[CH:32]1[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]1>>[ClH:20].[CH:25]1[N:24]2[CH:27]=[CH:28][CH:29]=[C:23]2[CH:22]=[C:21]([C:9]2[O:10][C:11]3[C:16]([C:7](=[N:6][OH:5])[CH:8]=2)=[CH:15][C:14]([O:17][CH2:18][CH2:19][N:35]2[CH2:36][CH2:37][CH:32]([C:31]([F:39])([F:38])[F:30])[CH2:33][CH2:34]2)=[CH:13][CH:12]=3)[N:26]=1

Participants

3

Reactant 2

HCID 1364694-(Trifluoromethyl)piperidineHCID 866730766-(2-chloro-ethoxy)-2-pyrrolo[1,2-c]pyrimidin-3-yl-chromen-4-one O-tert-butyl oxime

Product 1

HCID 131732484HCID 131732484, compound

Procedure

2-pyrrolo[1,2-c]pyrimidin-3-yl-6-[2-(4-trifluoromethyl-piperidin-1-yl)-ethoxy]chromen-4-one oxime, hydrochloride was prepared in 34% overall yield using the method described in example 87, starting from 6-(2-chloro-ethoxy)-2-pyrrolo[1,2-c]pyrimidin-3-yl-chromen-4-one O-tert-butyl oxime (example 87B) and 4-trifluoromethyl-piperidine.

Workup

  1. customoverall yield

Sources & evidence

ORD record
ord-22b86c982436425da3103eb8d3fdc102
Source dataset
uspto-grants-2015_02
Patent number
US08962627B2

Reaction notes

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