1-(2-chloroethyl)-1H-imidazole hydrochloride → 6-(2-Imidazol-1-yl-ethoxy)-2-pyrrolo[1,2-a]pyrazin-3-yl-chromen-4-one oxime, hydrochloride

HRID 1853340Notes

Reaction equation

HRID 1853340 reaction equation
C([O:5][N:6]=[C:7]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([OH:17])[CH:15]=2)[O:10][C:9]([C:18]2[N:19]=[CH:20][C:21]3[N:22]([CH:24]=[CH:25][CH:26]=3)[CH:23]=2)=[CH:8]1)(C)(C)C.Cl.[Cl:28][CH2:29][CH2:30][N:31]1[CH:35]=[CH:34][N:33]=[CH:32]1>>[ClH:28].[N:31]1([CH2:30][CH2:29][O:17][C:14]2[CH:15]=[C:16]3[C:11](=[CH:12][CH:13]=2)[O:10][C:9]([C:18]2[N:19]=[CH:20][C:21]4[N:22]([CH:24]=[CH:25][CH:26]=4)[CH:23]=2)=[CH:8][C:7]3=[N:6][OH:5])[CH:35]=[CH:34][N:33]=[CH:32]1

Participants

3

Reactant 2

HCID 27575031-(2-chloroethyl)-1H-imidazole hydrochlorideHCID 866730976-Hydroxy-2-pyrrolo[1,2-a]pyrazin-3-yl-chromen-4-one O-tert-butyl-oxime

Product 1

HCID 1317324916-(2-Imidazol-1-yl-ethoxy)-2-pyrrolo[1,2-a]pyrazin-3-yl-chromen-4-one oxime, hydrochloride

Procedure

6-(2-Imidazol-1-yl-ethoxy)-2-pyrrolo[1,2-a]pyrazin-3-yl-chromen-4-one oxime, hydrochloride was prepared in 13% overall yield using the method described in example 123, starting from 6-Hydroxy-2-pyrrolo[1,2-a]pyrazin-3-yl-chromen-4-one O-tert-butyl-oxime (example 123B) and 1-(2-Chloro-ethyl)-1H-imidazole hydrochloride.

Workup

  1. customoverall yield

Sources & evidence

ORD record
ord-1dc26d65eb6f4e5bbdad6748a3454b6f
Source dataset
uspto-grants-2015_02
Patent number
US08962627B2

Reaction notes

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