1-(2-Chloroethyl)-3,3-difluoropyrrolidine Hydrochloride → 6-[2-(3,3-Difluoro-pyrrolidin-1-yl)-ethoxy]-2-thieno[3,2-c]pyridin-6-yl-chromen-4-one oxime, hydrochloride

Participants

Role	Name	HCID	Charge
Reactant	1-(2-Chloroethyl)-3,3-difluoropyrrolidine Hydrochloride	HCID 67197404	—
Reactant	6-Hydroxy-2-thieno[3,2-c]pyridin-6-yl-chromen-4-one O-tert-butyl-oxime	HCID 86673101	—
Product	6-[2-(3,3-Difluoro-pyrrolidin-1-yl)-ethoxy]-2-thieno[3,2-c]pyridin-6-yl-chromen-4-one oxime, hydrochloride	HCID 137187586	—

Reaction Steps

6-[2-(3,3-Difluoro-pyrrolidin-1-yl)-ethoxy]-2-thieno[3,2-c]pyridin-6-yl-chromen-4-one oxime, hydrochloride was prepared in 62% overall yield using the method described in example 127, starting from 6-Hydroxy-2-thieno[3,2-c]pyridin-6-yl-chromen-4-one O-tert-butyl-oxime (example 127B) and 1-(2-Chloro-ethyl)-3,3-difluoro-pyrrolidine hydrochloride (WO2008/86404).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08962627B2
Source dataset	uspto-grants-2015_02
ORD ID	ord-9046dd4bbdd64a41bc6a7680c2a3fa4b
Source note	uspto-grants-2015_02