Acetyl chloride → HCID 117652296, compound

HRID 1853393Notes

Reaction equation

HRID 1853393 reaction equation
[NH2:1][C:2]1[O:3][C:4]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[C:5]([CH3:7])[N:6]=1.CCN(C(C)C)C(C)C.[C:22](Cl)(=[O:24])[CH3:23]>C(Cl)Cl>[C:22]([NH:1][C:2]1[O:3][C:4]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[C:5]([CH3:7])[N:6]=1)(=[O:24])[CH3:23]

Participants

5

Reactant 3

HCID 6367Acetyl chlorideHCID 81531DiisopropylethylamineHCID 12753431Ethyl 2-amino-4-methyl-1,3-oxazole-5-carboxylate

Product 1

HCID 117652296HCID 117652296, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

To 2 g (11.8 mmol) ethyl 2-amino-4-methyl-oxazole-5-carboxylate in 50 ml DCM are added 6.1 ml (35.3 mmol) DIPEA. To this mixture 0.92 ml (12.9 mmol) acetyl chloride are added and the reaction mixture is stirred at r.t. for 2 h. The mixture is diluted with further DCM and washed with water. The organic layer is separated, dried and the solvent is removed in vacuo.

Workup

  1. washwashed with water
  2. customThe organic layer is separated
  3. customdried
  4. customthe solvent is removed in vacuo

Sources & evidence

ORD record
ord-10f424622d344174a448a910e1fbc9ca
Source dataset
uspto-grants-2015_02
Patent number
US08962641B2

Reaction notes

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