Ammonia → HCID 49872636, compound

HRID 1853412Notes

Reaction equation

HRID 1853412 reaction equation
[NH2:1][N:2]1[C:7](=[O:8])[C:6]2[S:9][CH:10]=[CH:11][C:5]=2[N:4]=[CH:3]1.[C:12]12([CH2:22][C:23](Cl)=[O:24])[CH2:21][CH:16]3[CH2:17][CH:18]([CH2:20][CH:14]([CH2:15]3)[CH2:13]1)[CH2:19]2.N>>[C:12]12([CH2:22][C:23]([NH:1][N:2]3[C:7](=[O:8])[C:6]4[S:9][CH:10]=[CH:11][C:5]=4[N:4]=[CH:3]3)=[O:24])[CH2:19][CH:18]3[CH2:17][CH:16]([CH2:15][CH:14]([CH2:20]3)[CH2:13]1)[CH2:21]2

Participants

4

Reactant 3

HCID 222AmmoniaHCID 27718821-Adamantaneacetyl chlorideHCID 2777639HCID 2777639, compound

Product 1

HCID 49872636HCID 49872636, compound

Procedure

3-Amino-3,4-dihydrothieno[3,2-d]pyrimidin-4-one and 1-adamantaneacetyl chloride were reacted as described in Example 1: 1H NMR (300 MHz, DMSO-d6) δ ppm 1.57-1.68 (m, 12H), 1.94 (br s, 3H), 2.10 (s, 2H), 7.46 (d, J=5.4 Hz, 1H, 11.15 (s, 1H) ppm; MS (DCI/NH3) m/z 344 (M+H)+.

Sources & evidence

ORD record
ord-4b18a07de57b4b5cb86c6d1f8dfb9bbb
Source dataset
uspto-grants-2015_02
Patent number
US08962639B2

Reaction notes

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