HCID 1537019, compound → HCID 49872911, compound

HRID 1853418Notes

Reaction equation

HRID 1853418 reaction equation
[NH2:1][N:2]1[C:7](=[O:8])[C:6]2[CH:9]=[C:10]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[S:11][C:5]=2[N:4]=[CH:3]1.[C:18]12([CH2:28][C:29](Cl)=[O:30])[CH2:27][CH:22]3[CH2:23][CH:24]([CH2:26][CH:20]([CH2:21]3)[CH2:19]1)[CH2:25]2>>[C:18]12([CH2:28][C:29]([NH:1][N:2]3[C:7](=[O:8])[C:6]4[CH:9]=[C:10]([C:12]5[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=5)[S:11][C:5]=4[N:4]=[CH:3]3)=[O:30])[CH2:25][CH:24]3[CH2:23][CH:22]([CH2:21][CH:20]([CH2:26]3)[CH2:19]1)[CH2:27]2

Participants

3

Reactant 2

HCID 1537019HCID 1537019, compoundHCID 27718821-Adamantaneacetyl chloride

Product 1

HCID 49872911HCID 49872911, compound

Procedure

3-Amino-6-phenylthieno[2,3-d]pyrimidin-4(3H)-one and 1-adamantaneacetyl chloride were reacted as described in Example 5 to provide the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 1.65-1.75 (m, 12H), 2.01-2.05 (m, 3H), 2.23 (s, 2H), 7.35-7.46 (m, 3H), 7.63-7.65 (m, 2H), 7.69 (s, 1H), 7.99 (s, 1H), 8.10 (s, 1H); MS (DCI/NH3) m/z 420 (M+H)+; Elemental Analysis: Calculated for C24H25N3O2S: C, 68.71; H, 6.01; N, 10.02. Found: C, 68.53; H, 5.65; N, 9.98.

Sources & evidence

ORD record
ord-fe8d1664d82043deb3f94ef1417b0f98
Source dataset
uspto-grants-2015_02
Patent number
US08962639B2

Reaction notes

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