BRN 5958851 → HCID 49872915, compound

HRID 1853425Notes

Reaction equation

HRID 1853425 reaction equation
[C:1]12([CH2:11][C:12](Cl)=[O:13])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.[NH2:15][N:16]1[C:21](=[O:22])[C:20]2[C:23]3[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26][C:24]=3[S:25][C:19]=2[N:18]=[C:17]1[CH3:31]>>[C:1]12([CH2:11][C:12]([NH:15][N:16]3[C:21](=[O:22])[C:20]4[C:23]5[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26][C:24]=5[S:25][C:19]=4[N:18]=[C:17]3[CH3:31])=[O:13])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2

Participants

3

Reactant 2

HCID 2168926BRN 5958851HCID 27718821-Adamantaneacetyl chloride

Product 1

HCID 49872915HCID 49872915, compound

Procedure

1-Adamantaneacetyl chloride and 3-amino-2-methyl-3,5,6,7,8,9-hexahydro-4H-cyclohepta[4,5]thieno[2,3-d]pyrimidin-4-one (Matrix) were processed using the method described in Example 42C to afford the title compound. 1H NMR (500 MHz, DMSO-d6) δ ppm 1.49-1.76 (m, 15 H) 1.78-1.89 (m, 2 H) 1.91-2.00 (m, 3 H) 2.08 (d, J=15.0 Hz, 1 H) 2.16 (d, J=15.0 Hz, 1 H) 2.34 (s, 3 H) 2.84 (s, 2 H) 3.11-3.29 (m, 3 H) 10.76 (s, 1 H); MS (ESI+) m/z 426 (M+H)+.

Sources & evidence

ORD record
ord-33e70ce03bc4497382323f9f217765c7
Source dataset
uspto-grants-2015_02
Patent number
US08962639B2

Reaction notes

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