Hydrochloric Acid → HCID 71150033, compound

HRID 1853448Notes

Reaction equation

HRID 1853448 reaction equation
C[O:2][C:3]1[N:8]=[C:7]([O:9]C)[C:6]([C:11]2[CH:26]=[CH:25][C:14]([CH2:15][CH2:16][NH:17]C(=O)OC(C)(C)C)=[CH:13][CH:12]=2)=[CH:5][N:4]=1.[ClH:27]>>[ClH:27].[NH2:17][CH2:16][CH2:15][C:14]1[CH:13]=[CH:12][C:11]([C:6]2[C:7](=[O:9])[NH:8][C:3](=[O:2])[NH:4][CH:5]=2)=[CH:26][CH:25]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 71150046HCID 71150046, compound

Product 1

HCID 71150033HCID 71150033, compoundYield 86%

Procedure

To tert-butyl 4-(2,4-dimethoxypyrimidin-5-yl)phenethylcarbamate (0.5 g, 1.39 mmol) was added aqueous hydrochloric acid (6 M, 15 mL) and the reaction mixture stirred at reflux for 4 hours. No starting material was observed by LCMS. The precipitate was filtered, washed with water (5 mL) and dried under reduced pressure (50° C.) to give a pale yellow solid, 5-(4-(2-aminoethyl)phenyl)pyrimidine-2,4(1H,3H)-dione hydrochloride (0.32 g, 1.35 mmol, 86%).

Workup

  1. temperatureat reflux for 4 hours
  2. filtrationThe precipitate was filtered
  3. washwashed with water (5 mL)
  4. customdried under reduced pressure (50° C.)

Sources & evidence

ORD record
ord-84e1ae673fdc4830a7c44223306dc665
Source dataset
uspto-grants-2015_02
Patent number
US08962646B2

Reaction notes

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