Hydrogen Peroxide → 2,3-Difluorophenol

Into a 500 mL round-bottom flask, was placed a solution of (2,3-difluorophenyl)-boronic acid (30 g, 189.98 mmol, 1.00 equiv) in dichloromethane (250 mL). H2O2 (30 mL) was added dropwise with stirring. The resulting solution was stirred for 2 h at 25° C. The resulting mixture was washed with water and brine, dried over anhydrous magnesium sulfate and concentrated under vacuum to give 23 g (93%) of 2,3-difluorophenol as brown oil.

1. customInto a 500 mL round-bottom flask, was placed
2. stirringThe resulting solution was stirred for 2 h at 25° C
3. washThe resulting mixture was washed with water and brine
4. dry with materialdried over anhydrous magnesium sulfate
5. concentrationconcentrated under vacuum

ORD record

ord-e3cf84edf756454d9a19f5741bc9a1e7

Source dataset

uspto-grants-2015_02

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08962635B2