Hydrochloric Acid → HCID 86689461, compound

HRID 1853695Notes

Reaction equation

HRID 1853695 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[C:11]([CH3:13])[C:10]2[NH:9][C:8](=[O:14])[C:7]3[S:15][CH:16]=[CH:17][C:6]=3[C:5]=2[C:4]=1[C:18]1[CH:23]=[CH:22][C:21]([CH:24]([CH:34]([CH3:36])[CH3:35])[CH2:25][NH:26]C(=O)OC(C)(C)C)=[CH:20][CH:19]=1.[ClH:37]>CCOCC>[ClH:37].[NH2:26][CH2:25][CH:24]([C:21]1[CH:20]=[CH:19][C:18]([C:4]2[C:5]3[C:6]4[CH:17]=[CH:16][S:15][C:7]=4[C:8](=[O:14])[NH:9][C:10]=3[C:11]([CH3:13])=[CH:12][C:3]=2[O:2][CH3:1])=[CH:23][CH:22]=1)[CH:34]([CH3:35])[CH3:36]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86689452HCID 86689452, compound

Product 1

HCID 86689461HCID 86689461, compoundYield 92%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Following General Procedure D1, tert-butyl 2-(4-(8-methoxy-6-methyl-4-oxo-4,5-dihydrothieno[2,3-c]quinolin-9-yl)phenyl)-3-methylbutylcarbamate (50 mg, 0.060 mmol) was reacted with HCl in ether (3 mL) to afford the desired product (37 mg, 92%) as an off-white solid: ESI MS m/1407 [C24H26N2O2S+H]+.

Sources & evidence

ORD record
ord-ebb18236607a4ce8903bd8e010f6f9bc
Source dataset
uspto-grants-2015_02
Patent number
US08962648B2

Reaction notes

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