Hydrochloric Acid → HCID 86689464, compound

HRID 1853698Notes

Reaction equation

HRID 1853698 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[C:11]([CH3:13])[C:10]2[NH:9][C:8](=[O:14])[C:7]3[S:15][CH:16]=[CH:17][C:6]=3[C:5]=2[C:4]=1[C:18]1[CH:23]=[CH:22][C:21]([C@@H:24]([CH2:34][CH3:35])[CH2:25][NH:26]C(=O)OC(C)(C)C)=[CH:20][CH:19]=1.[ClH:36]>CCOCC>[ClH:36].[NH2:26][CH2:25][C@@H:24]([C:21]1[CH:20]=[CH:19][C:18]([C:4]2[C:5]3[C:6]4[CH:17]=[CH:16][S:15][C:7]=4[C:8](=[O:14])[NH:9][C:10]=3[C:11]([CH3:13])=[CH:12][C:3]=2[O:2][CH3:1])=[CH:23][CH:22]=1)[CH2:34][CH3:35]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86689455HCID 86689455, compound

Product 1

HCID 86689464HCID 86689464, compoundYield 94%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Following General Procedure D1, (R)-tert-butyl 2-(4-(8-methoxy-6-methyl-4-oxo-4,5-dihydrothieno[2,3-c]quinolin-9-yl)phenyl)butylcarbamate (100 mg, 0.20 mmol) was reacted with HCl in ether (10 mL) to afford the desired product (75 mg, 94%) as an off-white solid: ESI MS m/z 393 [C23H24N2O2S+H]+.

Sources & evidence

ORD record
ord-764bd1cc334f4fcbaebc0250d21dea20
Source dataset
uspto-grants-2015_02
Patent number
US08962648B2

Reaction notes

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