Hydrochloric Acid → HCID 67447164, compound

HRID 1853700Notes

Reaction equation

HRID 1853700 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[C:11]([CH3:13])[C:10]2[NH:9][C:8](=[O:14])[C:7]3[S:15][CH:16]=[CH:17][C:6]=3[C:5]=2[C:4]=1[C:18]1[CH:23]=[CH:22][C:21]([CH:24]([CH:35]([CH3:37])[CH3:36])[CH2:25][N:26](C)[C:27](=O)OC(C)(C)C)=[CH:20][CH:19]=1.[ClH:38]>CCOCC>[ClH:38].[CH3:1][O:2][C:3]1[CH:12]=[C:11]([CH3:13])[C:10]2[NH:9][C:8](=[O:14])[C:7]3[S:15][CH:16]=[CH:17][C:6]=3[C:5]=2[C:4]=1[C:18]1[CH:23]=[CH:22][C:21]([CH:24]([CH:35]([CH3:37])[CH3:36])[CH2:25][NH:26][CH3:27])=[CH:20][CH:19]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68226050tert-Butyl 2-(4-(8-methoxy-6-methyl-4-oxo-4,5-dihydrothieno[2,3-c]quinolin-9-yl)phenyl)-3-methylbutyl(methyl)carbamate

Product 1

HCID 67447164HCID 67447164, compoundYield 47%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Following General Procedure D1, tert-butyl 2-(4-(8-methoxy-6-methyl-4-oxo-4,5-dihydrothieno[2,3-c]quinolin-9-yl)phenyl)-3-methylbutyl(methyl)carbamate (100 mg, 0.2 mmol) was reacted with HCl in ether (8 mL) to afford the desired product (40 mg, 47%) as an off-white solid: ESI MS m/z 421 [C25H28N2O2S+H]+

Sources & evidence

ORD record
ord-11d5dc6dbbfd4ba0a6acb3ffa18f088e
Source dataset
uspto-grants-2015_02
Patent number
US08962648B2

Reaction notes

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