Phthalimide → HCID 86689562, compound

HRID 1853901Notes

Reaction equation

[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]([CH3:11])[CH2:9]O)=[C:4]([F:12])[CH:3]=1.[C:13]1(=[O:23])[NH:17][C:16](=[O:18])[C:15]2=[CH:19][CH:20]=[CH:21][CH:22]=[C:14]12>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]([CH3:11])[CH2:9][N:17]2[C:13](=[O:23])[C:14]3[C:15](=[CH:19][CH:20]=[CH:21][CH:22]=3)[C:16]2=[O:18])=[C:4]([F:12])[CH:3]=1

Participants

Reactant 2

HCID 6809Phthalimide

HCID 68226106HCID 68226106, compound

Product 1

HCID 86689562HCID 86689562, compoundYield 69%

Procedure

Following the procedure described for Example 633, (R)-2-(4-bromo-2-fluorophenyl)propan-1-ol (1.5 mg, 6.4 mmol) was reacted with phthalimide (1.0 mg, 7.008 mmol) to obtain the desired product (1.6 g, 69%) as a white solid: ESI MS m/z 363 [C17H13BrFNO2+H]+

Sources & evidence

ORD record: ord-2c8bdb40b2b84a9ebeee0e32b9f703d5
Source dataset: uspto-grants-2015_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08962648B2

Reaction notes

Loading…