Ammonium Chloride → HCID 86689573, compound

HRID 1853931Notes

Reaction equation

HRID 1853931 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([N:11]2[CH2:15][CH2:14][C@H:13]([NH:16][C:17](=[O:23])[O:18][C:19]([CH3:22])([CH3:21])[CH3:20])[CH2:12]2)[CH:5]=[CH:6][C:7]=1[N+:8]([O-])=O.[Cl-].[NH4+]>C(O)C.O.[Fe]>[NH2:8][C:7]1[CH:6]=[CH:5][C:4]([N:11]2[CH2:15][CH2:14][C@H:13]([NH:16][C:17](=[O:23])[O:18][C:19]([CH3:20])([CH3:21])[CH3:22])[CH2:12]2)=[CH:3][C:2]=1[Br:1]

Participants

6

Reactant 2

HCID 25517Ammonium ChlorideHCID 86689572HCID 86689572, compound

Product 1

HCID 86689573HCID 86689573, compoundYield 99.3%

Reagents, catalysts & solvents 3

HCID 23925IronCatalystHCID 702EthanolSolventHCID 962WaterSolvent

Procedure

A solution of (S)-tert-butyl 1-(3-bromo-4-nitrophenyl)pyrrolidin-3-ylcarbamate (2.5 g, 6.5 mmol), ammonium chloride (380 mg, 7.1 mmol), and iron (1.8 g, 32 mmol) in ethanol (20 mL) and water (10 mL) was heated to reflux for 1 h. The reaction mixture was cooled to room temperature and filtered through diatomaceous earth. The filtrate was concentrated to afford the desired product (2.3 g, >99%) as a blue solid: ESI MS m/z 357 [C15H22BrN3O2+H]+.

Workup

  1. temperatureto reflux for 1 h
  2. filtrationfiltered through diatomaceous earth
  3. concentrationThe filtrate was concentrated

Sources & evidence

ORD record
ord-29a678121cc54f6895ebf730416fe84e
Source dataset
uspto-grants-2015_02
Patent number
US08962648B2

Reaction notes

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