Tert-Butylamine → HCID 86718732, compound

HRID 1854184Notes

Reaction equation

[C:1]([C:5]1[CH:6]=[C:7]([CH:23]=O)[C:8]([OH:22])=[C:9]([C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[C:13]([C:18]([F:21])([F:20])[F:19])[CH:12]=2)[CH:10]=1)([CH3:4])([CH3:3])[CH3:2].[C:25]([NH2:29])([CH3:28])([CH3:27])[CH3:26]>>[ClH:17].[C:1]([C:5]1[CH:10]=[C:9]([C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[C:13]([C:18]([F:21])([F:20])[F:19])[CH:12]=2)[C:8]([OH:22])=[C:7]([CH2:23][NH:29][C:25]([CH3:28])([CH3:27])[CH3:26])[CH:6]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

Reactant 2

HCID 6385Tert-Butylamine

HCID 86718731HCID 86718731, compound

Product 1

HCID 86718732HCID 86718732, compound

Procedure

5-(tert-Butyl)-3-((tert-butylamino)methyl)-4′-chloro-3′-(trifluoromethyl)-[1,1′-biphenyl]-2-ol hydrochloride was prepared as a white solid using the procedure described in Example 9 from 5-(tert-butyl)-4′-chloro-2-hydroxy-3′-(trifluoromethyl)-[1,1′-biphenyl]-3-carbaldehyde and tert-butylamine. HPLC/MS Rt=7.41 min, m/z 414.1 and 416.1 (M+H+).

Sources & evidence

ORD record: ord-c7e2828671c94fbda35a57827bb77b62
Source dataset: uspto-grants-2015_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08962657B2

Reaction notes

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