Tert-Butylamine → HCID 86718759, compound

HRID 1854201Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:14]=[C:13]([O:15][C:16]([F:19])([F:18])[F:17])[CH:12]=[C:11]([CH:20]=O)[C:10]=2[OH:22])[CH:5]=[CH:6][C:7]=1[Cl:8].[C:23]([NH2:27])([CH3:26])([CH3:25])[CH3:24]>>[ClH:1].[C:23]([NH:27][CH2:20][C:11]1[CH:12]=[C:13]([O:15][C:16]([F:17])([F:19])[F:18])[CH:14]=[C:9]([C:4]2[CH:5]=[CH:6][C:7]([Cl:8])=[C:2]([Cl:1])[CH:3]=2)[C:10]=1[OH:22])([CH3:26])([CH3:25])[CH3:24]

Participants

Reactant 2

HCID 6385Tert-Butylamine

HCID 86718761HCID 86718761, compound

Product 1

HCID 86718759HCID 86718759, compound

Procedure

3-((tert-Butylamino)methyl)-3′,4′-dichloro-5-(trifluoromethoxy)-[1,1′-biphenyl]-2-ol hydrochloride was prepared as a white solid using the procedure described in Example 9 from 3′,4′-dichloro-2-hydroxy-5-(trifluoromethoxy)-[1,1′-biphenyl]-3-carbaldehyde and tert-butylamine.

Sources & evidence

ORD record: ord-8a8fbadcc13a4582a253b0333ffcf949
Source dataset: uspto-grants-2015_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08962657B2

Reaction notes

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