Tert-Butylamine → 5'-((tert-Butylamino)methyl)-3,3''-dichloro-4,4''-bis(trifluoromethyl)-[1,1':3',1''-terphenyl]-4'-ol

HRID 1854210Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([C:12]2[CH:17]=[C:16]([CH:18]=O)[C:15]([OH:20])=[C:14]([C:21]3[CH:26]=[CH:25][C:24]([C:27]([F:30])([F:29])[F:28])=[C:23]([Cl:31])[CH:22]=3)[CH:13]=2)[CH:5]=[CH:6][C:7]=1[C:8]([F:11])([F:10])[F:9].[C:32]([NH2:36])([CH3:35])([CH3:34])[CH3:33]>>[C:32]([NH:36][CH2:18][C:16]1[C:15]([OH:20])=[C:14]([C:21]2[CH:26]=[CH:25][C:24]([C:27]([F:29])([F:28])[F:30])=[C:23]([Cl:31])[CH:22]=2)[CH:13]=[C:12]([C:4]2[CH:5]=[CH:6][C:7]([C:8]([F:11])([F:10])[F:9])=[C:2]([Cl:1])[CH:3]=2)[CH:17]=1)([CH3:35])([CH3:34])[CH3:33]

Participants

Reactant 2

HCID 6385Tert-Butylamine

HCID 867187723,3''-Dichloro-4'-hydroxy-4,4''-bis(trifluoromethyl)-[1,1':3',1''-terphenyl]-5'-carbaldehyde

Product 1

HCID 867187735'-((tert-Butylamino)methyl)-3,3''-dichloro-4,4''-bis(trifluoromethyl)-[1,1':3',1''-terphenyl]-4'-ol

Procedure

5′-((tert-Butylamino)methyl)-3,3″-dichloro-4,4″-bis(trifluoromethyl)-[1,1′:3′,1″-terphenyl]-4′-ol was prepared as a white solid using the procedure described in Example 5 from 3,3″-dichloro-4′-hydroxy-4,4″-bis(trifluoromethyl)-[1,1′:3′,1″-terphenyl]-5′-carbaldehyde and tert-butylamine.

Sources & evidence

ORD record: ord-d883ac9bfd74489cae43c49870a852b7
Source dataset: uspto-grants-2015_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08962657B2

Reaction notes

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