HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2S,4R)-ethyl 4-(dibenzylamino)-2-ethyl-1-methylcyclopentanecarboxylate → (2S,4R)-ethyl 4-amino-2-ethyl-1-methylcyclopentanecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2S,4R)-ethyl 4-(dibenzylamino)-2-ethyl-1-methylcyclopentanecarboxylate | HCID 58010117 | — |
| Reactant | (2R,4S)-ethyl 4-(dibenzylamino)-2-ethyl-1-methylcyclopentanecarboxylate | HCID 58010228 | — |
| Product | (2R,4S)-ethyl 4-amino-2-ethyl-1-methylcyclopentanecarboxylate | HCID 58009848 | — |
| Product | (2S,4R)-ethyl 4-amino-2-ethyl-1-methylcyclopentanecarboxylate | HCID 58009886 | 100% |
Reaction Steps
A mixture of (2R,4S)-ethyl 4-(dibenzylamino)-2-ethyl-1-methylcyclopentanecarboxylate and (2S,4R)-ethyl 4-(dibenzylamino)-2-ethyl-1-methylcyclopentanecarboxylate (0.864 g, 2.28 mmol) was debenzylated using General Procedure FF to give (2R,4S)-ethyl 4-amino-2-ethyl-1-methylcyclopentanecarboxylate and (2S,4R)-ethyl 4-amino-2-ethyl-1-methylcyclopentanecarboxylate (0.45 g, 100%). LC/MS (Table 2, Method a) Rt=1.55 min; MS m/z: 200 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08962629B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-159d1095734547b7977eb942796c026a |
| Source note | uspto-grants-2015_02 |