Sodium Hydroxide → 5-Amino-1-phenyl-1H-pyrazole-3-carboxylic acid

HRID 1854525Notes

Reaction equation

HRID 1854525 reaction equation
[NH2:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:5]=[C:4]([C:13]([O:15]CC)=[O:14])[CH:3]=1.[OH-].[Na+]>CCO>[NH2:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:5]=[C:4]([C:13]([OH:15])=[O:14])[CH:3]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 23630921Ethyl 5-amino-1-phenyl-1H-pyrazole-3-carboxylate

Product 1

HCID 233360985-Amino-1-phenyl-1H-pyrazole-3-carboxylic acidYield 65%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2 g (8.65 mmol) of ethyl 5-amino-1-phenyl-1H-pyrazole-3-carboxylate are dissolved in 20 ml EtOH and 20 ml of 1M NaOH solution are added. The mixture is stirred overnight, the solvent removed in vacuo and the crude product subject to HPLC chromatography: Yield: 65%

Workup

  1. customthe solvent removed in vacuo

Sources & evidence

ORD record
ord-b72cc373c3ff4338887adf24861b0448
Source dataset
uspto-grants-2015_02
Patent number
US08962671B2

Reaction notes

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