HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 5-Amino-1-phenyl-1H-pyrazole-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ethyl 5-amino-1-phenyl-1H-pyrazole-3-carboxylate | HCID 23630921 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-Amino-1-phenyl-1H-pyrazole-3-carboxylic acid | HCID 23336098 | 65% |
Reaction Steps
2 g (8.65 mmol) of ethyl 5-amino-1-phenyl-1H-pyrazole-3-carboxylate are dissolved in 20 ml EtOH and 20 ml of 1M NaOH solution are added. The mixture is stirred overnight, the solvent removed in vacuo and the crude product subject to HPLC chromatography: Yield: 65%
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08962671B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-b72cc373c3ff4338887adf24861b0448 |
| Source note | uspto-grants-2015_02 |