反应详情

温度

17.5 °C

Add acetyl chloride (562.79 g, 7.17 mol) to methanol (10.00 L) at 0° C. in an appropriate vessel. Heat the mixture to 17.5° C. and stir. After 30 minutes, add 2-bromo-D-phenylalanine (500.00 g, 2.05 moles) and heat to reflux. After 4 hours, cool to 20° C. and remove the solvent under reduced pressure to give the title compound (589 g, 1.96 mol) as an off-white solid. MS (m/z): 258 (M-Cl (79Br)), 260 (M-Cl (81Br)).

1. temperatureheat to reflux
2. waitAfter 4 hours
3. temperaturecool to 20° C.
4. customremove the solvent under reduced pressure