HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1854541Generated: October 30, 2026
Acetyl chloride → methyl 2-bromo-D-phenylalaninate hydrochloride
https://huagongshe.com/reaction/1854541
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | (2R)-2-amino-3-(2-bromophenyl)propanoic acid | HCID 7023575 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | methyl 2-bromo-D-phenylalaninate hydrochloride | HCID 117720502 | 95.6% |
Reaction Steps
Add acetyl chloride (562.79 g, 7.17 mol) to methanol (10.00 L) at 0° C. in an appropriate vessel. Heat the mixture to 17.5° C. and stir. After 30 minutes, add 2-bromo-D-phenylalanine (500.00 g, 2.05 moles) and heat to reflux. After 4 hours, cool to 20° C. and remove the solvent under reduced pressure to give the title compound (589 g, 1.96 mol) as an off-white solid. MS (m/z): 258 (M-Cl (79Br)), 260 (M-Cl (81Br)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08962654B2 |
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| Source dataset | uspto-grants-2015_02 |
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| ORD ID | ord-81884e92c1654979820814e45f033481 |
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| Source note | uspto-grants-2015_02 |
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