反应详情

温度

20 °C

Add water (2.94 L) and sodium hydrogen carbonate (648.25 g, 7.64 mol) to methyl 2-bromo-D-phenylalaninate hydrochloride (580 g, 1.91 mol) in dichloromethane (9.86 L) at 10° C. in an appropriate vessel. After 5 minutes add methyl chloroformate (198.53 g, 2.10 mol) and stir the mixture at 20° C. After 3 hours add water (2.5 L) and separate the layers. Extract the aqueous with dichloromethane, dry the combined organic extracts over sodium sulfate and concentrate under reduced pressure to give the title compound (556 g, 1.74 mol). MS (m/z): 315.8 (M+1 (79Br)), 317.8 (M+1 (81Br)).

1. customseparate the layers
2. extractionExtract the aqueous with dichloromethane
3. dry with materialdry the combined organic extracts over sodium sulfate
4. concentrationconcentrate under reduced pressure