反应详情

A solution of 3-iodobenzyl chloride (100 mg, 0.396 mmol) in 1,4-dioxane (3 ml) was treated with pyrrolidine (0.5 ml, 6.02 mmol) and heated to reflux for 5 h. The cooled mixture was evaporated to dryness and treated with EtOAc and water. The organics were separated, dried over MgSO4, filtered and evaporated to afford 1-(3-iodo-benzyl)-pyrrolidine as a clear syrup (110 mg, 97%).

1. temperatureheated
2. temperatureto reflux for 5 h
3. customThe cooled mixture was evaporated to dryness
4. additiontreated with EtOAc and water
5. customThe organics were separated
6. dry with materialdried over MgSO4
7. filtrationfiltered
8. customevaporated