HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperazin-2-one → 4-{5-[6-(5-Methyl-thiazol-2-ylamino)-pyridin-2-yl]-oxazol-2-yl}-piperazin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperazin-2-one | HCID 231360 | — |
| Reactant | 5-[6-(4-methylpyridin-2-ylamino)pyridin-2-yl]-N-(pyridin-4-ylmethyl)oxazol-2-amine | HCID 67345865 | — |
| Reactant | [6-(2-Chloro-oxazol-5-yl)-pyridin-2-yl]-(5-methyl-thiazol-2-yl)-amine | HCID 86676500 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 4-{5-[6-(5-Methyl-thiazol-2-ylamino)-pyridin-2-yl]-oxazol-2-yl}-piperazin-2-one | HCID 86676499 | — |
Reaction Steps
Prepared as for 5-[6-(4-methylpyridin-2-ylamino)pyridin-2-yl]-N-(pyridin-4-ylmethyl)oxazol-2-amine above from [6-(2-Chloro-oxazol-5-yl)-pyridin-2-yl]-(5-methyl-thiazol-2-yl)-amine and 2-oxopiperazine in iPrOH. 1H NMR (400 MHz, DMSO-d6) δ 11.08 (s, 1H), 8.14 (s, 1H), 7.68 (t, J=7.9 Hz, 1H), 7.59 (s, 1H), 7.16-6.97 (m, 2H), 6.83 (d, J=8.2 Hz, 1H), 4.11 (s, 2H), 3.86-3.63 (m, 2H), 3.43-3.32 (m, 2H), 2.37 (s, 3H). (ESI+) m/z 357 (M+H)+. Retention time=1.91 mins (method 1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08962665B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-afd8822563504ef7a8340853764b4bf3 |
| Source note | uspto-grants-2015_02 |