反应详情

Prepared as for 5-[6-(4-methylpyridin-2-ylamino)pyridin-2-yl]-N-(pyridin-4-ylmethyl)oxazol-2-amine above from [6-(2-Chloro-oxazol-5-yl)-pyridin-2-yl]-(5-methyl-thiazol-2-yl)-amine and 2-oxopiperazine in iPrOH. 1H NMR (400 MHz, DMSO-d6) δ 11.08 (s, 1H), 8.14 (s, 1H), 7.68 (t, J=7.9 Hz, 1H), 7.59 (s, 1H), 7.16-6.97 (m, 2H), 6.83 (d, J=8.2 Hz, 1H), 4.11 (s, 2H), 3.86-3.63 (m, 2H), 3.43-3.32 (m, 2H), 2.37 (s, 3H). (ESI+) m/z 357 (M+H)+. Retention time=1.91 mins (method 1).