Dimethylacetamide → N-[[4-[4-[2-(hydroxymethyl)pyrrolidin-1-yl]butoxymethyl]cyclohexyl]methyl]-N-methyl-4-(trifluoromethyl)benzenesulfonamide

HRID 185461Notes

Reaction equation

HRID 185461 reaction equation
[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][O:6][CH2:7][CH:8]1[CH2:9][CH2:10][CH:11]([CH2:14][N:15]([S:16](=[O:17])(=[O:18])[c:19]2[cH:20][cH:21][c:22]([C:25]([F:26])([F:27])[F:28])[cH:23][cH:24]2)[CH3:29])[CH2:12][CH2:13]1.[CH3:37][N:38]([CH3:39])[C:40](=[O:41])[CH3:42].[OH:30][CH2:31][CH:32]1[NH:33][CH2:34][CH2:35][CH2:36]1>>[CH2:2]([CH2:3][CH2:4][CH2:5][O:6][CH2:7][CH:8]1[CH2:9][CH2:10][CH:11]([CH2:14][N:15]([S:16](=[O:17])(=[O:18])[c:19]2[cH:20][cH:21][c:22]([C:25]([F:26])([F:27])[F:28])[cH:23][cH:24]2)[CH3:29])[CH2:12][CH2:13]1)[N:33]1[CH:32]([CH2:31][OH:30])[CH2:36][CH2:35][CH2:34]1

Participants

4

Reactant 3

HCID 31374DimethylacetamideHCID 90908ProlinolHCID 22294178trans-N-[4-(4-bromo-butoxymethyl)-cyclohexylmethyl]-N-methyl-4-trifluoromethyl-benzenesulfonamide

Product 1

HCID 22294234N-[[4-[4-[2-(hydroxymethyl)pyrrolidin-1-yl]butoxymethyl]cyclohexyl]methyl]-N-methyl-4-(trifluoromethyl)benzenesulfonamide

Sources & evidence

ORD record
ord-e0741644c9c648189624df026853de17
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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