HCID 68551182, compound → HCID 68554115, compound

HRID 1854685Notes

Reaction equation

HRID 1854685 reaction equation
C(OC([NH:8][CH2:9][C:10]([NH:12][C:13]1[CH:18]=[CH:17][C:16](/[CH:19]=[CH:20]/[C:21](=[O:34])[CH2:22][C:23](=[O:33])/[CH:24]=[CH:25]/[C:26]2[CH:31]=[CH:30][C:29]([OH:32])=[CH:28][CH:27]=2)=[CH:15][CH:14]=1)=[O:11])=O)(C)(C)C.C(OC(NC1C=CC(/C=C/C(=O)CC(=O)/C=C/C2C=CC(O)=CC=2)=CC=1)=O)(C)(C)C>C(Cl)(Cl)Cl.CO>[NH2:8][CH2:9][C:10]([NH:12][C:13]1[CH:14]=[CH:15][C:16](/[CH:19]=[CH:20]/[C:21](=[O:34])[CH2:22][C:23](=[O:33])/[CH:24]=[CH:25]/[C:26]2[CH:31]=[CH:30][C:29]([OH:32])=[CH:28][CH:27]=2)=[CH:17][CH:18]=1)=[O:11]

Participants

4

Reactant 2

HCID 68551182HCID 68551182, compoundHCID 68551771HCID 68551771, compound

Product 1

HCID 68554115HCID 68554115, compound

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

The title compound was synthesized using the same procedure employed for Example 281, but with (1E,6E)-1-{4-[2-(tert-butoxycarbonylamino)acetylamino]phenyl}-7-(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione (18 mg, 39 μmol, synthesized in Example 268) as the starting material instead of (1E,6E)-1-[4-(tert-butoxycarbonylamino)phenyl]-7-(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione, and was purified by silica gel chromatography (chloroform/methanol=95/5 to 80/20). The product was obtained as a solid (1.5 mg, 11%) having the following characteristic.

Sources & evidence

ORD record
ord-a476c9f7b5334091a3f5e06d92fe56fa
Source dataset
uspto-grants-2015_02
Patent number
US08962674B2

Reaction notes

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