HCID 68551182, compound → HCID 68556127, compound

HRID 1854686Notes

Reaction equation

HRID 1854686 reaction equation
C(OC([N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14](/[CH:17]=[CH:18]/[C:19](=[O:32])[CH2:20][C:21](=[O:31])/[CH:22]=[CH:23]/[C:24]3[CH:29]=[CH:28][C:27]([OH:30])=[CH:26][CH:25]=3)[CH:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.C(OC(NC1C=CC(/C=C/C(=O)CC(=O)/C=C/C2C=CC(O)=CC=2)=CC=1)=O)(C)(C)C>C(Cl)(Cl)Cl.CO>[OH:30][C:27]1[CH:28]=[CH:29][C:24](/[CH:23]=[CH:22]/[C:21](=[O:31])[CH2:20][C:19](=[O:32])/[CH:18]=[CH:17]/[C:14]2[CH:15]=[C:16]3[C:11]([CH2:10][CH2:9][NH:8]3)=[CH:12][CH:13]=2)=[CH:25][CH:26]=1

Participants

4

Reactant 2

HCID 68551182HCID 68551182, compoundHCID 68551589HCID 68551589, compound

Product 1

HCID 68556127HCID 68556127, compound

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

The title compound was synthesized using the same procedure employed for Example 281, but with (1E,6E)-1-[1-(tert-butoxycarbony)-indolin-6-yl]-7-(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione (14 mg, 32 μmol, synthesized in Example 292) as the starting material instead of (1E,6E)-1-[4-(tert-butoxycarbonylamino)phenyl]-7-(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione, and was purified by silica gel chromatography (chloroform/methanol=100/0 to 95/5). The product was obtained as a solid (1.4 mg, 13%) having the following characteristic.

Sources & evidence

ORD record
ord-bbe8407fcbbb4cbb8f8f0915c46b1e9c
Source dataset
uspto-grants-2015_02
Patent number
US08962674B2

Reaction notes

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