HCID 49806006, compound → HCID 68553421, compound

HRID 1854707Notes

Reaction equation

HRID 1854707 reaction equation
[CH2:1]([N:3]1[C:15]2[CH:14]=[CH:13][C:12](/[CH:16]=[CH:17]/[C:18](=[O:33])[CH2:19][C:20](=[O:32])/[CH:21]=[CH:22]/[C:23]3[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[C:25]([OH:31])[CH:24]=3)=[CH:11][C:10]=2[C:9]2[C:4]1=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH3:2].CN(C)C1C=CC(/C=C/C(=O)CC(=O)/C=C/C2C=CC(O)=C(OC)C=2)=CC=1>>[CH2:1]([N:3]1[C:15]2[CH:14]=[CH:13][C:12]([CH2:16][CH2:17][C:18](=[O:33])[CH2:19][C:20](=[O:32])[CH2:21][CH2:22][C:23]3[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[C:25]([OH:31])[CH:24]=3)=[CH:11][C:10]=2[C:9]2[C:4]1=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH3:2]

Participants

3

Reactant 2

HCID 49806006HCID 49806006, compoundHCID 68549362HCID 68549362, compound

Product 1

HCID 68553421HCID 68553421, compound

Procedure

The title compound was synthesized using the same procedure employed for Example 372, but with (1E,6E)-1-(9-ethyl-9H-carbazol-3-yl)-7-(3-hydroxy-4-methoxyphenyl)hepta-1,6-diene-3,5-dione (20 mg, 59 μmol, synthesized in Example 84) as the starting material instead of (1E,6E)-1-(4-dimethylaminophenyl)-7-(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione, and was purified by silica gel column chromatography eluting with hexane/ethyl acetate=75/25 to 65/35. The product was obtained as a solid (13.1 mg, 65%) having the following characteristics.

Workup

  1. washeluting with hexane/ethyl acetate=75/25 to 65/35

Sources & evidence

ORD record
ord-8359c52e6ff64698a9e34623c6f6fbe2
Source dataset
uspto-grants-2015_02
Patent number
US08962674B2

Reaction notes

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