2-Chloro-4,6-dimethoxy-1,3,5-triazine → 3-(4,6-dimethoxy-1,3,5-triazin-2-yl)-5,7-difluoro-1,3-dihydro-2H-indol-2-one

HRID 1854771Notes

Reaction equation

HRID 1854771 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([F:11])[CH:10]=1)[NH:7][C:6](=[O:12])[CH2:5]2.Cl[C:14]1[N:19]=[C:18]([O:20][CH3:21])[N:17]=[C:16]([O:22][CH3:23])[N:15]=1>>[CH3:23][O:22][C:16]1[N:17]=[C:18]([O:20][CH3:21])[N:19]=[C:14]([CH:5]2[C:4]3[C:8](=[C:9]([F:11])[CH:10]=[C:2]([F:1])[CH:3]=3)[NH:7][C:6]2=[O:12])[N:15]=1

Participants

3

Reactant 2

HCID 184502-Chloro-4,6-dimethoxy-1,3,5-triazineHCID 27789635,7-difluoro-1,3-dihydro-2H-indol-2-one

Product 1

HCID 679830153-(4,6-dimethoxy-1,3,5-triazin-2-yl)-5,7-difluoro-1,3-dihydro-2H-indol-2-one

Procedure

5,7-Difluoro-1,3-dihydro-2H-indol-2-one (1.69 g) and 2-chloro-4,6-dimethoxy-1,3,5-triazine (2.13 g) are reacted analogously to Example 1 Variant A. This gives the title compound as solid in an HPLC purity of 93% area (2.82 g, 85% of theory).

Sources & evidence

ORD record
ord-c4a011ec440c452fb85dd099dc73a91f
Source dataset
uspto-grants-2015_02
Patent number
US08962828B2

Reaction notes

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