Barium hydroxide → HCID 131732511, compound

HRID 1854787Notes

Reaction equation

HRID 1854787 reaction equation
[CH3:1][C:2]1[O:6][C:5]([C:7]([NH:9][C:10]([C:13]2[N:19]([CH3:20])[C:17](=[O:18])[C:16]([OH:21])=[C:15]([C:22]([NH:24][CH2:25][C:26]3[CH:27]=[CH:28][C:29]([F:32])=[CH:30][CH:31]=3)=[O:23])[N:14]=2)([CH3:12])[CH3:11])=[O:8])=[N:4][N:3]=1.[OH-].[Ba+2:34].[OH-]>C(O)C>[CH3:1][C:2]1[O:6][C:5]([C:7]([NH:9][C:10]([C:13]2[N:19]([CH3:20])[C:17](=[O:18])[C:16]([OH:21])=[C:15]([C:22]([NH:24][CH2:25][C:26]3[CH:27]=[CH:28][C:29]([F:32])=[CH:30][CH:31]=3)=[O:23])[N:14]=2)([CH3:12])[CH3:11])=[O:8])=[N:4][N:3]=1.[Ba:34]

Participants

4

Reactant 2

HCID 6093286Barium hydroxideHCID 54671008Raltegravir

Product 1

HCID 131732511HCID 131732511, compoundYield 80.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
62.5 °C

Procedure

Raltegravir (100 gm) was suspended in ethanol (600 ml) and then added barium hydroxide (42 gm) at 25 to 30° C. The contents were heated to 60 to 65° C. to obtain a solution. The solution was cooled to 25 to 30° C. and stirred for 18 hours at 25 to 30° C. The solid obtained was collected by filtration and dried to obtain 105 gm of raltegravir barium.

Workup

  1. customat 25 to 30° C
  2. customto obtain a solution
  3. temperatureThe solution was cooled to 25 to 30° C.
  4. customThe solid obtained
  5. filtrationwas collected by filtration
  6. customdried

Sources & evidence

ORD record
ord-6c3a4115a4324566ae3524c093654727
Source dataset
uspto-grants-2015_02
Patent number
US08962833B2

Reaction notes

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