HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 86676668, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Phenol, 2-chloro-5-(trifluoromethyl)- | HCID 123498 | — |
| Reactant | 4-(2-(Trifluoromethyl)phenoxy)piperidine hydrochloride | HCID 17178004 | — |
| Reactant | tert-Butyl [(1R,2R)-2-(hydroxymethyl)cyclopropyl]carbamate | HCID 24720934 | — |
| Product | HCID 86676668 | HCID 86676668 | — |
Reaction Steps
The intermediate 1f is synthesised according to the procedure described for the synthesis of 1a from 2-chloro-5-(trifluoromethyl)phenol and trans-(2-hydroxymethyl-cyclopropyl)-carbamic acid tert-butyl ester and, the amine function deprotection step is carried out in an HCl solution (4N in dioxane). 1f is isolated in solid form with a 95% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08962837B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-72e7c89a4bdb45fe84a9eb8102b97123 |
| Source note | uspto-grants-2015_02 |