Hydrochloric Acid → HCID 86676668, compound

HRID 1854806Notes

Reaction equation

HRID 1854806 reaction equation
Cl.FC(F)(F)C1C=CC=CC=1O[CH:7]1[CH2:12]C[NH:10][CH2:9][CH2:8]1.[Cl:19][C:20]1[CH:25]=[CH:24][C:23]([C:26]([F:29])([F:28])[F:27])=[CH:22][C:21]=1[OH:30].C(OC(=O)N[C@@H]1C[C@H]1CO)(C)(C)C.Cl>>[ClH:19].[Cl:19][C:20]1[CH:25]=[CH:24][C:23]([C:26]([F:28])([F:29])[F:27])=[CH:22][C:21]=1[O:30][CH2:12][C@@H:7]1[CH2:8][C@H:9]1[NH2:10]

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 123498Phenol, 2-chloro-5-(trifluoromethyl)-HCID 171780044-(2-(Trifluoromethyl)phenoxy)piperidine hydrochlorideHCID 24720934tert-Butyl [(1R,2R)-2-(hydroxymethyl)cyclopropyl]carbamate

Product 1

HCID 86676668HCID 86676668, compound

Procedure

The intermediate 1f is synthesised according to the procedure described for the synthesis of 1a from 2-chloro-5-(trifluoromethyl)phenol and trans-(2-hydroxymethyl-cyclopropyl)-carbamic acid tert-butyl ester and, the amine function deprotection step is carried out in an HCl solution (4N in dioxane). 1f is isolated in solid form with a 95% yield.

Workup

  1. customThe intermediate 1f is synthesised

Sources & evidence

ORD record
ord-72e7c89a4bdb45fe84a9eb8102b97123
Source dataset
uspto-grants-2015_02
Patent number
US08962837B2

Reaction notes

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