HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1854807Generated: October 26, 2026
Oxalyl chloride → 3,5-Dichloro-1-methyl-1,2-dihydropyrazin-2-one
https://huagongshe.com/reaction/1854807
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | Acetonitrile, 2-(methylamino)-, hydrochloride (1:1) | HCID 117641 | — |
| Solvent | 1,2-Dichlorobenzene | HCID 7239 | — |
| Product | 3,5-Dichloro-1-methyl-1,2-dihydropyrazin-2-one | HCID 13062968 | 60.8% |
Reaction Steps
3.29 g (30.8 mmoles) of methylamino-acetonitrile hydrochloride is placed in the presence of 19.6 g (154 mmoles) of oxalyl chloride in 30 ml of 1,2-dichlorobenzene. The mixture is heated for 8 hours at 80° C. After concentrating the reaction medium to dryness, the residue obtained is purified by flash chromatography (Petroleum ether-CH2Cl2 gradient 100-0 to 0-100). 3.35 g of intermediate 4c is obtained in beige powder form (yield: 60%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08962837B2 |
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| Source dataset | uspto-grants-2015_02 |
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| ORD ID | ord-fbeeb1286590426a8f7b14de02b2d71d |
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| Source note | uspto-grants-2015_02 |
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