反应详情

温度

80 °C

3.29 g (30.8 mmoles) of methylamino-acetonitrile hydrochloride is placed in the presence of 19.6 g (154 mmoles) of oxalyl chloride in 30 ml of 1,2-dichlorobenzene. The mixture is heated for 8 hours at 80° C. After concentrating the reaction medium to dryness, the residue obtained is purified by flash chromatography (Petroleum ether-CH2Cl2 gradient 100-0 to 0-100). 3.35 g of intermediate 4c is obtained in beige powder form (yield: 60%).

1. concentrationAfter concentrating the reaction medium to dryness
2. customthe residue obtained
3. customis purified by flash chromatography (Petroleum ether-CH2Cl2 gradient 100-0 to 0-100)